Growing flu viruses in eggs can introduce changes (called egg-adapted changes) that can cause differences between the viruses in the vaccine and the ones that are circulating. What is the significance of FDA approving cell-based candidate vaccine viruses for use in the Flucelvax Quadrivalent cell-based flu vaccines? Learn more about the cell-based flu vaccine manufacturing process on CDC’s How Flu Vaccines are Made web page. For the 2020-2021 season, the viruses provided to the manufacturer to be grown in cell culture are cell-derived rather than egg-derived. The cell-based vaccine manufacturing process uses animal cells (Madin-Darby Canine Kidney, or MDCK cells) as a host for the growing flu viruses instead of fertilized chicken eggs. How is the cell-based vaccine manufacturing process different than the traditional egg-based manufacturing process? In one study published in the Journal of Infectious Diseases external icon among Medicare beneficiaries 65 years and older, cell-based vaccine provided greater protection against flu-related hospitalizations than standard-dose, egg based vaccine.įor the 2020-2021 flu season, all four flu viruses used in the Flucelvax Quadrivalent are cell-derived, making the vaccine egg-free. The viruses used to make cell-based vaccines may be more similar to circulating “wild” flu viruses than the viruses used to make egg-based vaccines. In addition, cell-based flu vaccines that use cell-based candidate vaccine viruses (CVVs) have the potential to offer better protection than traditional, egg-based flu vaccines.
Why has a cell-based flu vaccine been developed?Ĭell-based flu vaccine production does not use flu viruses grown in eggs and, therefore, is not dependent on the supply of eggs. Who can get Flucelvax Quadrivalent?įlucelvax Quadrivalent is licensed for use in people 6 months and older. The flu viruses used in the cell-based vaccines are grown in cultured cells of mammalian origin instead of in hens’ eggs.įlucelvax Quadrivalent is the only cell-based inactivated flu vaccine that has been licensed by the FDA for use in the United States. Most inactivated flu vaccines are produced by growing flu viruses in eggs. ‘Cell-based’ refers to how the influenza (flu) vaccine is made.
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